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Promestriene has a more unique effect on sebaceous glands

2020-09-24 00:00:00

  International Journal of Cosmetic Science 2,315-329 (1980) 

  J. GIRARD and A. BARBIER, 

  Centre de Recherches Clin Midy, Rue du Prof. Blayac, F-34082 Montpellier Cedex, France J、 GIRARD A.BARBIER 


Summary  

The aim of this work is to evaluate the predictable nature in human therapeutics of results obtained with some anti-seborrhoeic drugs in various experimental tests performed in vitro or in uivo on animal models. This correlative study applies to antiseborrhoiec drugs (mainly of the hormonal type) for which the results of tests based on objective measurement criteria (secretion of sebum, synthesis of sebaceous lipids, height and mitoses number of sebaceous gland) are available in the animal as well as in man (literature references or assays performed in our laboratory). Natural or more often synthetic oestrogens are currently used in women with 0145-5463/80/1200-0315 1980 International Journal of Cosmetic Science 315 31 6 J. Girard and A. Barbier seborrhoea or acne, as an oral contraceptive drug and, more recently, as a local therapy in both sexes. Benefits of such utilisation have been well assessed by assays on animal models in which powerful oestrogen derivatives (ethinyl estradiol, diethylstilboestrol) are actually active by systemic administration on the sebaceous target as well as on the sexual organs. Nevertheless a more specific action on the sebaceous gland has been found for other less powerful estrogen derivatives (promestriene or CM 4727). The topic use may yet be criticised because the inhibition observed in the animal is usually a systemic one and, on the other hand, depending on the animal chosen and its sex, the results may not be in agreement with those described for human tests. Among the anti-androgen antiseborrhoeic drugs, the activity of compounds like cyproterone acetate is well evidenced after systemic administration, in respect to secretion of sebum as well as mitoses in man and in animals. However, this moderately specific activity cannot be found after topical administration in man even at high doses. On the other hand, in the animal (hamster flank organ) the local anti-seborrhoeic effect is highly linked to the sex of the animal chosen. As far as progesterone, described as an anti-androgenic drug locally active in inhibiting 5-alpha reductase, is concerned, a close relationship seems to appear between animal and human tests in respect with the dissociation of the anti-seborrhoeic effects according to sex; progesterone is able to inhibit the female hamster sebaceous lipogenesis as well as the seborrhoea of acneic women, at least temporarily. Yet it does not seem to be active in man or in the male hamster (laboratory findings). Finally, the activity of non-hormonal drugs, described as ‘anti-seborrhoeic’ in man (clofibrate, S. carboxy methyl L cysteine, eicosa tetraynoic acid) is very difficult to assess in laboratory animal models. This comparative study thus confirms that predicting the antiseborrhoeic activity of drugs in man from results with the animal is by no means easy and that choosing the animal model is most important and highly dependent on the compound to be tested. 


Introduction 

The object of this work is to appreciate the predictive value in human therapy of information obtained for certain antiseborrhic substances in different tests Experimental study in vitro or in vivo (treatment by local or general route). This study of correlations is limited to antisiborrhoids, mainly of the hormonal results for which results, based on objective measurement criteria (sicrition sibacee, sibaceous lipid synthesis, size and number of sibaceous gland mitoses) are available both in animals and in humans in works, either taken from the literature, or made in our laboratory. The plan adopted for this study is that of the therapeutic classes which have been or are currently used in human seborrhea.