Product Details

【Usage & Synthesis】 

Lenalidomide is an anti-tumor drug developed by Celgene biopharmaceutical company in the United States. Its chemical structure is similar to thalidomide, and it has multiple effects such as anti-tumor, immune regulation and anti-angiogenesis. It can inhibit the secretion of proinflammatory cytokines and increase the secretion of anti-inflammatory cytokines in peripheral blood monocytes.In vitro tests showed that the drug inhibited proliferation of certain cell lines such as Namalwa cells.Leinalidomide inhibited the growth of multiple myeloma cells and MM1S cells in patients. In addition, this product can also inhibit the expression of cox-2 (cox-2), but it has no effect on cox-1.Two multicentre randomized, blind, placebo-controlled clinical studies evaluated the safety and efficacy of leinalidomide in multiple myeloma. The main endpoints of the studies were disease progression time (TTP) interim analysis, and the TTP in the combination group was significantly superior to that in the dexamethasone group.Recent clinical studies have shown that, in addition to treating MDS and MM, leidomide is effective in treating myeloma, leukemia, metastatic renal cell carcinoma, solid tumor, primary systemic amyloidosis, and systemic myelofibrosis with myelogenesis.Lenalidomide is a new generation of derivatives of thalidomide, but it has not been found to have teratogenic toxicity and is 100 times more effective than thalidomide.According to phase iii clinical trials, lenalidomide is currently the most effective treatment for multiple myeloma, extending survival by more than three years in more than half of patients.It was also the only drug that was effective in the treatment of myelodysplastic syndrome (MDS), and clinical results showed that 64% of MDS patients treated with nalidomide did not need blood transfusions to treat MDS. 

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